Both the CDC and the medical textbook co-authored by Paul Offit say that HUB is a concerning issue when getting a clear picture of the true safety and efficacy of vaccines. You saying that’s not the case or not what they are saying doesn’t make it so.
As I’ve already stipulated, their significant concerns don’t stop them because they don’t see other good ways to ethically do tests. That doesn’t mean that we shouldn’t still push for better, as these study results amply indicate.
“DTP was associated with 5-fold higher mortality than being unvacci-
nated. No prospective study has shown beneficial survival effects of
DTP. Unfortunately, DTP is the most widely used vaccine, and the pro-
portion who receives DTP3 is used globally as an indicator of the perfor-
mance of national vaccination programs.
It should be of concern that the effect of routine vaccinations on all-
cause mortality was not tested in randomized trials. All currently avail-
able evidence suggests that DTP vaccine may kill more children from
other causes than it saves from diphtheria, tetanus or pertussis. Though
a vaccine protects children against the target disease it may simulta-
neously increase susceptibility to unrelated infections.
The recently published SAGE review called for randomized trials of
DTP (Higgins et al., 2014). However, at the same time the IVIR-AC com-
mittee to which SAGE delegated the follow-up studies of the NSEs of
vaccines has indicated that it will not be possible to examine the effect
of DTP in an unbiased way. If that decision by IVIR-AC remains unchal-
lenged, the present study may remain the closest we will ever come
to a RCT of the NSEs of DTP.”
journal homepage:
Please cite this article as: Mogensen, S.W., et al., The Introduction of Diphtheria-Tetanus-Pertussis and Oral Polio Vaccine Among Young Infants in
an Urban African Community: A Natur…, EBioMedicine (2017),
